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Feature highlights: |
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C30 carbon chain |
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high carbon load of 22% |
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large pH stability range |
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applicable for 100% aqueous eluents |
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high stability towards special chromatographic conditions |
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YMC’s product portfolio reflects the practical expertise in applying liquid chromatography for demanding separations, day after day - year after year, reproducibly and efficiently. The following chapter has been designed to outline a variety of chromatography tools that are found to be extremely useful in advanced working environments such as combinatorial chemistry, LC-MS, method development, validation and scale-up. |
PRODUCT |
CODE |
PHASE
(silica-based
unless noted) |
END
CAP-PED |
USP
CLASS
NO. |
PART.
SIZE |
PORE SIZE (nm) |
CAR-
BON LOAD
(%C) |
pH |
TYPICAL
APPLI-
CATIONS |
YMC30
|
CT |
proprietary polymeric bonding chemistry |
pro-prietary |
– |
3, 51 |
pro-prietary |
– |
2-6 |
isomeric carotenes, retinols, steroids, fat-soluble vitamins |
| ProC18 |
AS |
latest generation C18 using ultrapure silica base (99.999%), with very low
residual non-specific interactions |
yes |
L1 |
2, 3, 51 |
12 |
16 |
2-8 |
fat-soluble vitamins, antioxidants, metabolites, acidic,
neutral, basic and chelating compounds |
ProC18RS
|
RS |
high carbon load with polymeric bonding C18,
ultrapure silica base (99,999%) |
yes |
L1 |
3, 5 |
8 |
22 |
1-102 |
suitable for a wide range of samples including acidic and
basic compounds |
Hydro-sphere
C18
|
HS |
based on the same ultrapure silica base as ProFamily,
can be used
in 100% aqueous eluent |
yes |
L1 |
3, 5 |
12 |
12 |
2-8 |
strong polar compounds, antibiotics, catechol-amines, nucleic acids.
water-soluble vitamins, acidic, neutral, basic and chelating compounds |
| ODS-A |
AA |
one of YMC’s international bestsellers, traditional high performance
C18 column |
yes |
L1 |
3, 51 |
12, 20, 30 |
17, 12, 7 |
2-7.5 |
pharmaceuticals, vitamins, amino acids, peptides,
general purpose phase |
| ODS-AM |
AM |
strict QC controlled production provides a high performance
C18 column for validated methods operations |
yes |
L1 |
3, 51 |
12 |
17 |
2-7.5 |
purines, phenols, PTC-amino acids, angiotensins, alkaloids |
ODS-AQ
|
AQ |
"hydrophilic" endcapping, for 100% aqueous eluent systems,
substantially increased retention of polar compounds |
yes |
L1 |
3, 51 |
12, 20 |
14, 10 |
2-7.5 |
strong polar compounds, pharmaceuticals,
antibiotics, peptides and proteins, nucleic acids |
J´sphere
|
JH, JM,
JL |
C18-family with differently controlled hydrophobicity for
method development |
yes |
L1 |
4 |
8 |
22, 14, 9
(JH, JM, JL) |
1-9 (H)
2-7.5 (M+L) |
positional isomers, complexing agents, pharmaceuticals |
| ODS-AL |
AL |
traditional C18 for "mixed mode" separations |
no |
L1 |
3, 5 |
12 |
17 |
2-7.5 |
tocopherols, fat-soluble vitamins, disinfectants |
Polymer
C18
|
PC |
polymethacrylate-matrix, stable towards shrinking and
swelling, wide pH applicability |
- |
- |
6, 101 |
pro-prietary |
C18 equiv.
10% |
2-13 |
phenols, anilines, peptides in high pH, pharmaceuticals,
quaternary amines |
| ProC8 |
OS |
latest generation C8 using ultrapure silica base (99.999%), with very low
residual non-specific interactions |
yes |
L7 |
3, 5 |
12 |
10 |
2-7.5 |
acidic, neutral, basic and chelating compounds, drugs and
metabolites |
| C8 (Octyl) |
OC |
traditional C8, high coverage monomeric bonding chemistry |
yes |
L7 |
3, 51 |
12, 20, 30 |
10, 7, 4 |
2-7.5 |
proteins and peptides, estrogens, general purpose phase |
| YMCbasic |
BA |
specifically designed for the separation of basic compounds |
- |
L7 |
3, 51 |
pro-prietary |
8 |
2-7.5 |
basic molecules w/o modifiers, anilines, alkaloids, anti-depressants |
| Phenyl |
PH |
monomeric bonded phenyl |
yes |
L11 |
3, 51 |
12, 30 |
9, 3 |
2-7.5 |
phenols, fullerenes, sweeteners |
| ProC4 |
BS |
latest generation C4 using ultrapure silica base (99.999%),
with very low residual non-specific interactions |
yes |
L26 |
3, 5 |
12 |
7 |
2-7.5 |
polar acidic, neutral, basic and chelating compounds, polar peptides |
| C4 (Butyl) |
BU |
traditional C4, high coverage monomeric bonding chemistry |
yes |
L26 |
3, 51 |
12, 20, 30 |
7, 5, 3 |
2-7.5 |
biological separations, polar compounds |
Protein RP
|
PR |
specifically designed to withstand exposure to TFA, good recovery rates |
yes |
L26 |
5 |
pro-prietary |
|
1.5-7.5 |
proteins,
peptides |
| C1 (TMS)3;4 |
TM |
trimethyl silane, excellent hydrolytic stability |
- |
L13 |
3, 51 |
12, 30 |
4, 3 |
2-7.5 |
water-soluble vitamins |
PVA-SIL
|
PV |
polyvinyl alcohol bonded on silica support, suitable for normal or
reversed phase applications |
- |
L24 |
5 |
12 |
- |
2-9.5 |
proteins, phospho-
lipids, retinoids, lipids |
Polyamine II
(PBMN)4
|
PB |
mixed secondary and tertiary amino derivative gives improved
hydrolytic stability and alternative selectivity compared to
conventional amino-phases, increased lifetime, rapid equilibration time |
- |
- |
5 |
12 |
- |
2-9 |
maltooligosaccha-rides, tocopherols, nucleotides, sugars |
| Amino3;4 |
NH |
primary amino derivative, high coverage monomeric bonding chemistry |
- |
L8 |
3, 51 |
12 |
3 |
2-7.5 |
sugars, nucleotides, water-soluble vitamins |
| Cyano3;4 |
CN |
traditional cyano derivative, useful also for SFC applications |
yes |
L10 |
3, 51 |
12, 30 |
7, 2.5 |
2-7.5 |
proteins, steroids, catechols |
| Diol3;4 |
DL |
for aqueous GPC or normal phase applications, high recovery of biological material |
- |
L20 |
51 |
6, 12, 20, 30 |
- |
5-7.5 (RP)
2-7.5 (NP)
|
peptides, proteins, malto-oligo-
saccharides |
| Silica4 |
SL |
ultra high purity, high mechanical stability |
- |
L3 |
3, 51 |
6, 12, 20, 30 |
- |
2-7.5 |
small organic molecules, fat-soluble vitamins, tocopherols |
1preparative grades routinely available (others on request)
2it is recommended to use at least 10% organic solvent composition near the pH limits and over 50% at pH values above pH 9.0 to preserve column lifetimes
3when ordering please specify normal or reserved phase
4applicable for HILIC-mode
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