In normal phase mode the YMC-Pack Diol stationary phase is a versatile alternative to silica. The bonded phase’s hydroxyl groups provide good selectivity without excessive retention, since hydrogen bonding with the diol layer is not as strong as with the silanols on a bare silica surface. Diol columns also provide improved reproducibility when compared with bare silica.
Diol packings are suitable for separations using reversed phase techniques or molecular weight determination of proteins by gel filtration.