Properties

The unique characteristics of b-cyclodextrin provide excellent stereospecific selectivity for the separation of enantiomers (mirror-image or optical isomers). The active chiral moiety, b-cyclodextrin, has a toroidal structure with a hydrophobic cavity formed with the glucoside oxygens and carbon backbones of the sugar residues, while a hydrophilic surface is formed with the primary and secondary hydroxy groups.

As the b-cyclodextrin ligands are bonded covalently to the silica support the phase shows excellent solvent resistance: Besides water, alcohol or acetonitrile also hexane, dichloromethane, THF and other organic solvents can be used as mobile phase.

The high ligand density provides excellent loadability and recovery, qualifying YMC chiral Prep CD one of the first choice packing materials for preparative chiral separations.

YMC Chiral Prep CD is suitable both for the conventional column separations and also for dynamic axial compression (DAC) columns and simulated moving bed (SMB) systems.

YMC Chiral Prep CD is available in large batch sizes up to several hundred kilograms with YMC's well known high quality, reproducibility and technical support. It provides a significant tool for downstream processing at pilot production scale.

Combined with the surprising cost-efficiency, YMC Chiral Prep CD will be of interest in developing or up-scaling chiral purification processes. In addition, method development is made easier by use of scouting columns for selectivity screening.