YMC*Gel Cyano

for normal, reversed phase and HILIC applications silica gel with cyanopropyl functionality faster column equilibration than normal silica gel most polar reversed phase column

General

In reversed phase mode, cyano phases are the most polar and least retentive of all reversed phase packings. Extremely hydrophobic compounds, which do not elute on standard C18 and C8 packings with typical reversed phase eluents, can be separated using cyano phases. Normal, reversed phase and HILIC separations can be carried out on this material.

Properties

YMC*Gel Cyano provides a different selectivity from both phenyl and standard aliphatic (C18, C8 or C4) reversed phase packings. It is useful for quick and simple analysis of compounds that differ greatly in hydrophobicity, without the need to use gradient elution chromatography.

Cyano packings also provide an alternative to silica in normal phase chromatography, where bonded normal phase packings have the advantage of faster equilibration, more uniform surface activity and increased resistance to dissolution than bare silica.
To extend column lifetime continued switching between normal and reversed phase solvents should be avoided.