Products : Preparative LC

YMC DAC Columns
Dynamic axial compression (DAC) columns for preparative scale liquid chromatography

General
Large scale preparative chromatography techniques are today’s purification method of choice for high value products in the pharmaceutical and biotech industry.
Due to technical advances and innovations in column technology and engineering in the last decade, industrial liquid chromatography has become a well established, convenient and economic process technique.

Working Principle (operating mode) of YMC DAC-Columns:

A hydraulic jack operates a piston that moves inside the chromatographic column. The piston is used to maintain a controlled dynamic pressure on the chromatographic bed during column operation as well as for packing and unpacking operations. The DAC system allows fast column packing of virtually any kind of packing material and assures excellent bed stability, reproducibility and efficiency in pilot or production columns.

YMC offers two types of column design to meet our customers’ specific process and site requirements:

DAU-Columns: The chromatographic column is mounted on top of the hydraulic jack; the column bed is compressed upwards. This assembly allows convenient packing either automatically via the slurry inlet near the bottom of the column or manually by dismantling the column top.

YMC DAU-Columns are available in two standard maximum bed lengths of 400 and 600 mm with inner diameters ranging from 50 to 600 mm and a pressure rating of 5 to 10 MPa (725 to 1450 psi). Versions with longer column beds are available on request.

DAD-Columns: The hydraulic jack is mounted on top of the chromatographic column and pressurizes the column bed downwards. The DAD-Column can be packed automatically via the slurry inlet near the top of the column and can be easily unpacked by pushing the column bed through the lower column lid.

Due to the compact design of this assembly the maximum chromatographic bed length is limited to 300 mm. DAD-Columns are available with inner diameters ranging from 100 to 450 mm and with pressure ratings of 5 to 10 MPa (725 to 1450 psi).

Alternatives designed to meet specific user requirements as well as additional features including slurry vessel, slurry inlets or double jackets for heating / cooling purposes are available on request.