High Surface Area:
YMC spherical silica supports are completely porous, providing a very high surface area for greater retention and increased resolution. In preparative applications, a high surface area also means greater sample loading and hence better throughput. High sample loading, excellent resolution and long column life combine to provide maximum productivity and economy in preparative separations.
Pore Size |
YMC*Gel |
(nm) |
(m2/g) |
| 6 |
650 |
| 12 |
330 |
| 20 |
175 |
| 30 |
100 |
Table 1: Comparison of surface areas:
Impact of Pore Size
YMC*Gel is available in up to five different pore sizes. Pore sizes are typically matched to sample molecule sizes. Pore sizes can also be used to adjust ligand density and hence retention characteristics of a bonded phase, since the size of the pores also affects the total media surface area in a packed column.
Please note extended molecular weight range when applying SEC.
YMC Pore Size Guide
| Pore Size |
Recommendation |
| 6 nm |
- For the separation of small organic molecules in NP or SEC mode.
- Very high surface area and loadability
- Available in YMC*Gel Silica for normal phase separations and in YMC*Gel Diol for normal phase separations and size exclusion chromatography
|
| 12 nm |
- Suitable for the majority of separations
- For most organic compounds
- For peptides less than 20 kDa
- Higher surface area and sample loading than 20 nm and 30 nm media.
|
| 20 nm |
- For peptides and smaller proteins from 10 kDa to 50 kDa
- For bulky organic compounds
- Higher surface area and higher sample loading than 30 nm media
|
| 30 nm |
- For large proteins and biomolecules larger than 40 kDa
- For organic compounds with excessive retention on smaller pore materials
|
|
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